The gang members appear only during the mission Running Dog. CJ and Big Smoke go to East Los Santons and meet the two. They engage in a short conversation during which the Vagos insult Smoke, which prompts him to beat one member up with a baseball bat while CJ chases and kills the other member.
Like Big Poppa and Freddy, they use a generic Vagos model. Big Smoke calls one member José, although he was most likely just being derogatory, as "José" is a common Spanish name.