- Vagos: "Hey, fuck you cabrón."
- Big Smoke: "Now that ain't nice. Coughio up el weedo, before I blow your brains out all over the patio. "
- Vagos: "Chinga a tu madre, pendejo."
- —The Vagos and Big Smoke
The gang members appear only during the mission Running Dog. CJ and Big Smoke go to East Los Santons and meet the two. They engage in a short conversation during which the Vagos insult Smoke, which prompts him to beat one member up with a baseball bat while CJ chases and kills the other member.
- Running Dog (Killed)