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The "Theme from San Andreas" is the theme song of Grand Theft Auto: San Andreas, featured in the opening video. It was written and produced by Michael Hunter. The song appears on the Grand Theft Auto: San Andreas: Official Soundtrack compilation, making it one of only four Grand Theft Auto themes to be officially released to date (the others being the "Theme from Vice City", "Soviet Connection" from Grand Theft Auto IV and "Welcome to Los Santos" from Grand Theft Auto V). An extended version of the song can be heard during the ending credits of the game, and a slightly different version plays over the loading screen after the opening video.

It is also used as the "Los Santos" horn in Grand Theft Auto Online, which was added as part of the GTA Online: Lowriders update.

Vice Lights, a song in the arcade game series, Race and Chase, is based off of this song.