The movie is about five teens who take LSD and discover the 'truth'. They actually live in a computer, and they have to supposedly "make the decision of their lives". According to the script of The Electron Zone, a radio show hosted on Liberty City Free Radio, the movie has a character who saves everyone, a defecating robot, and a metaphor of backdoor hacking, which Bill praises. Co-host Steve says that, in his honest opinion, the Mainframe is the greatest movie of all time. The movie also raised some controversy over cyber-sexism.
Narrator: The event movie of the year everyone is talking about.
Male #1: You're just a virus! You're not real!
Female #1: I'm your mother, stupid!
Narrator: A group of people who think the whole world is trapped in a computer.
Male #2: We can't get out!
Female #2: Hurry, stick your hard disc inside my drive.
Male #2: I can't! My hard disc crashed!
Female #2: Reboot it!
Narrator: The Mainframe. What happens when five college students take LSD, and discover the truth.
Male #1: AHH! Your face is a big pixel!
Narrator: They have to make the decision of their lives.
Female #3: What's it gonna be? Yes or no!? One or ZERO!?
Narrator: The Mainframe, it's real.
Female #3: Oh no! The MAINFRAME!
Narrator: Coming to theaters this Friday. Rated PS for "Pretty Stupid".
- With the exception of the girl to the right of Jock's character (she is a pedestrian seen within Bone County and Tierra Robada), all pedestrians in the poster had a role in Grand Theft Auto: San Andreas; The girl to the left was used as Sweet's Girlfriend, the man to the left was used as Alan Crawford, Jock's character is a model used for the members of the Da Nang Boys, and the last girl is Barbara Schternvart.
- This is the second movie in the game which uses Barbara's model in a movie poster, the other is the poster for Silent But Violent.
- The movie breaks the fourth wall of the gaming world, much like the soapboxers in Grand Theft Auto IV.