Much of Florida is on a peninsula between the Gulf of Mexico, the Atlantic Ocean and the Straits of Florida. Much of the state is at or near sea level, and is considered is the "flattest state in the United States" in real-life.
In both 2D Universe and 3D Universe, Vice City seems to be in the middle of the summer rainy season, having long, hot, humid days and occasional tropical thunderstorms.
The state is also exposed to hurricanes. In 1986, Hurricane Hermione was forecast to strike Vice City, which forced the closing of all bridges to and from the mainland. When the storm changed course before it could hit, the bridges were reopened.
The Miami metropolitan area, mentioned in Grand Theft Auto III and Grand Theft Auto: Vice City, with a population of almost 6.2 million, is the most populous urban area in Florida and the seventh-most populous in the United States in real-life. The real-world Miami is used as a basis for Vice City in all three universes.
The City of Vice, commonly known as Vice City or simply Vice, is a city first featured in the 1997's original Grand Theft Auto game, as part of the 2D Universe of the series, before being introduced in 3D Universe with Grand Theft Auto: Vice City and Grand Theft Auto: Vice City Stories, and later mentioned in the HD Universe titles.
In the 2D Universe, the city is a former Spanish slaving colony, and by 1997, during the events of the first Grand Theft Auto, Vice City has the highest murder rates, the highest amounts of drug-related crime and the least respected police department of anywhere in the United States. Vice City is the archetypal 'melting pot', with large Caribbean, Colombian and European communities, always feuding with another. One of the Rastafarian communities from Kingston, the Brotherhood of Jah Army of Love, has a large turf in the town. The city is also known as the City of the Fallen Angel in this universe. 
In both the 3D Universe, Vice City was a major cocaine trans-shipment point for South America during the 1980s, as seen during the events of Grand Theft Auto: Vice City an Grand Theft Auto: Vice City Stories. The city consists of two major islands and three smaller islands; both major islands are separated by the Ocean Bay, a large body of water which separates Vice Beach from the Mainland. Each major island is divided into several districts. The population of Vice City is given at around 1.8 million in 1986. .
While the city has yet to appear in the HD Universe, the city is still mentioned to be a major cocaine trans-shipment point. In Grand Theft Auto IV, the Charge Island Boatyard is used by the Russians to smuggle drugs from Vice City to Liberty City.
- Florida is one of five states featured in the series, the others being the states of Liberty, Alderney, San Andreas, New Guernsey, and North Yankton, but it is the only real-life state to appear.
- During the mission Jury Fury in GTA Vice City, Tommy calls a hit & run driver a "dumb Florida moron".
- In Grand Theft Auto IV, when asked by Eddie Low if he is from Liberty City, Niko Bellic sarcastically says: "No, I'm from Florida.".
- Official GTA website
- Page 5 of the Tourist Guide, GTA Vice City's game manual