Safehouses can be acquired through missions or through purchases. When the player purchases a safehouse, the player can use the touchscreen or a certain button to sign a deed confirming the purchase or void the deed to cancel the purchase. Safehouses not yet purchased are indicated by a blue house icon in the radar. Purchased safehouses are indicated by a green house icon. Safehouses that the player encounters can be viewed in the PDA.
The functionality of the interior of the safehouses differs dramatically from previous games. The player can use the touchscreen to browse around the safehouse. Along with the introduction of drug dealing, every safehouse has a stash box in which the player can stash collected drugs to free up space in the holdall or prevent the drugs from being taken by the police when busted. The whiteboard is used to replay previously completed story missions and to input cheats in the iPhone/iPod touch/Android versions. The laptop is used to upload stats using Nintendo's Wi-Fi connection, viewable on the Rockstar Games Social Club. The couch or chair is used to save the game to restore the player's health, remove wanted levels, and advance the game by six hours. The door is used to exit the safehouse. Rewards in the form of objects can be seen placed on shelves and on tables for the player to view.
A new feature to the safehouse is seclusion. During certain missions or hijacking certain vehicles with valuable contraband or weapons, the player must go to a secluded safehouse in order to search for them. Some safehouses include garages. Garages can only store one vehicle at a time.
Owning all 21 safehouses will reward the player with the Jeweled Key to the City and a step closer to 100% completion.
|Cerveza Heights Safehouse||Inchon Avenue, Cerveza Heights, Dukes||Yes||Yes||Yu Jian|
|Lancaster Safehouse||Lancaster, Algonquin||Yes||Yes||Carpe "Dime"|
|South Bohan Safehouse||San Quentin Avenue/Hollowback Street, South Bohan, Bohan||No||No||Raw Deal|
|Lower Easton Safehouse||Albany Avenue/Diamond Street, Lower Easton, Algonquin||Yes||No||Missed the Boat?|
|Northwood Safehouse||Xenotime Street, Northwood, Algonquin||Yes||No||Grave Situation|
|Meadow Hills Safehouse||Seymour Avenue, Meadow Hills, Dukes||Yes||No||Wilhelm's third encounter|
|The Star Plaza Hotel||Denver-Exeter Avenue, Star Junction, Algonquin||No||No||I'm Rich Scratch Cards|