Carl goes to Smoke's house. Upon arriving there, he finds Officer Frank Tenpenny and Officer Eddie Pulaski leaving. Smoke informs Carl that they are attempting to extract information from him. Smoke tells CJ that his cousin, Mary is coming to the town from Mexico and he's going to pick her up.
The two drive to a place to meet two Vagosgang members. After a short mixed Spanish conversation, Smoke knocks one out using a baseball bat while the other runs away. Carl manages to catch and kill him.
In order to complete the mission the player must:
Get into Big Smoke's car.
Drive Big Smoke to the meet. If you need a weapon, go to Emmet's house.
Chase down the gang member.
You can only use the Super Sprint for a short time before becoming tired.
The more you sprint, the higher your stamina will become, allowing you to exert yourself for longer.
Big Smoke says his cousin is called "Mary", which is a reference to Mary Jane, slang for marijuana.
This is the only mission given by Big Smoke where Carl is not required to use a motorbike.
However, even though he is required to use a yellow Sanchez in the next mission, he does not need to.
If the Sentinel is destroyed or the driver is killed before the Vago runs to it, he will just flee from the scene with a random NPC scream, giving the player time to kill him.
If the running Vago is killed while in sight of the Sentinel, after the mission is completed, the Sentinel driver will drive the vehicle away rapidly.
The Sentinel is locked if the driver is waiting for the Vago in it. If the driver is killed by whatever reason, Carl can enter the vehicle and it can be kept after killing the Vago, but it will lock itself if the player simply gets out of the car.
The line the second Vagos member uses roughly translates to, "fuck you, dumbass," and afterwards, "fuck your mother, asshole."
In this mission, it is revealed that Big Smoke knows how to speak (some) Spanish.
Earlier during the game's development, this mission also required Carl to drive Smoke back home. CJ asked Smoke about Tenpenny's visit at the start of the mission, which Smoke replied that he does not know who Tenpenny is. It is speculated that part was cut because it was strongly foreshadowing Smoke's betrayal. The part can be seen here.
After the mission, if Carl has over 50% fat, he will receive a phone call from Smoke shortly afterwards, who tells Carl that he is "letting himself go" and needs to visit the Gym, and Carl sarcastically declines his suggestion. This can be seen here.
This is the only time the interior of Big Smoke's house is seen (at least part of it). Outside of this cutscene, if managing to go through the building, the interior will be absent, as it is scripted to spawn only in the cutscene.
Though there's no monetary reward from completing the mission, the Vagos member drops a large amount of cash upon death, similar to other drug dealer pedestrians.
In some occasions, if the player attempts to shoot the running Vago in the head after he gets into the vehicle, not only will he drop money and a pistol, but also an extra Micro-SMG that he has used to perform a drive-by shooting on CJ.
The destination of the Vagos ride is the house with the green door in Las Colinas. This can be seen here