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Route 22 is one of the Numbered Highways in San Andreas. It is a major east-west urban highway that serves many locations in Los Santos, including the Los Santos International Airport, Maze Bank Arena and the Port of Los Santos. Although this highway is unsigned in game Route 22 is known as Dutch London Street for all of it's routing. Route 22 begins at the intersection with Interstate 5 and runs east with the intersection with Davis Avenue past the Maze Bank Arena. It crosses over the western section of the Los Santos Storm Drain (HD Universe) and crosses over the railroad tracks at the intersection with Roy Lowenstein Boulevard. Route 22's eastern end is at the intersection with Signal Street and El Rancho Boulevard in Banning while its western end is located at the junction with Calais Avenue and South Rockford Drive.

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