Queens appears to be home to most of San Fierro's gay, lesbian, bisexual, and transgender community. Because of this, many gay and lesbian couples can be seen holding hands or kissing. The neighborhood is bordered by City Hall to the west, Santa Flora to the north, Hashbury to the south and King's to the east.
The lamp posts have gay pride flags on them, which emit a pink glow at night.
According to Barbara Schternvart, the district has a high crime rate.
- Been Flickin'
- Biffin Bridge Hotel
- The Barbers Pole
- Gaydar Station
- Gaze Glasses
- Hippy Shopper
- Queens Hotel
- Queens Theater
- The Uphill Gardener Garden Center
- Vank Hoff Hotel
- Three snapshots
Judging by its name and appearance ("Queen" is a slang term for a homosexual male), Queens appears to be based on the Castro District of San Francisco, an area populated by the gay community. The wide boulevard winding up the hill is also meant to resemble Market Street in San Francisco that winds up Twin Peaks through the Castro.
- In the game's files there is also a power line post with a rainbow 'sock' on it meant for this area, however it is left unused.
- Despite Queens being an area populated by homosexuals, there are no ped models in the game that are specifically meant to be homosexual.