- It is a good idea to buy this Safehouse when doing the Mafia missions with the mission location just across the road.
- Along with the Casino name abbreviated as "PIMP", the safehouse name can be also be abbreviated to "PIMPS".
- Pirates in Men's Pants is a parody of the Opera The Pirates of Penzance.
- Its name and location on the Las Venturas strip is also a parody of the pirate themed Treasure Island Hotel and Casino located on the Las Vegas strip in Clark County, Nevada.
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