In Grand Theft Auto IV, Patriot Beer is sold in various restaurants including the 60 Diner on Albany Avenue in Algonquin, Liberty City. In Grand Theft Auto V, it can be found in Rob's Liquor, 24/7 and Limited Service stores. One of the liveries on the Sanchez is for Patriot Beer.
In addition to its beer the brand also sells merchandise including t-shirts which are worn by many members of The Lost Motorcycle Club. It is possible to obtain a Patriot Beer hat in GTA Online through the special crates after the Independence Day Special update has been installed.
Patriot Beer appears to have a large presence within the world of motorsports. Most noticeably, all the racing liveries for some vehicles in Grand Theft Auto Online which all feature a similar design with the flag on The United States of America.
- Dick from Republican Space Rangers claims that this is his favorite beer.
- In the Call of Duty: Modern Warfare 2 multiplayer map Trailer Park, there are beer bottles with writing on them: "Patriot beer: Genuine shitty taste".
- The two revolvers seen in the main logo are LeMat Revolvers, handguns previously featured in Red Dead Redemption.