Some rest areas can be recognized as those on the real-life road, offering views of the Vinewood Sign, the Vinewood Bowl, the Galileo Observatory, Lake Vinewood, and Downtown Los Santos. It has seven rest areas just like its real-life counterpart.
It is likely to be based on Mulholland Drive.
- The name is mostly likely inspired in the fictional detective Philip Marlowe, a private detective created by Raymond Chandler. The setting in Chandler's novels were based in Los Angeles, the city Los Santos is based on.
- It is possible that Marlowe Drive is named after a prominent unseen family in the game, as the Marlowe Vineyards are also in the game.