- "The world's on fire, man, when you swallow down Lithium!"
- — Station jingle
Lithium can only be heard in the Downtown District. It plays a random array of music, consisting of techno/dance music, Christian pop and classic soul. The mixed genre nature of its playlist is a reference to its mentally unstable owners, the Loonies gang, which have this station as their favorite.
Lithium is hosted by Spaz Funbags, voiced by actor Fred Newman. Spaz, like the Loonies, seems to be schizophrenic, and speaks in varying voices and pitches, making eccentric dialogues. However, he seems genuinely angry when the audio machine chews the record Tammy Boness & The Swingin' Mammaries' "The Diner", cutting the song short.
- The year of release for these songs is that of GTA 2: 1999.
- Authors of the songs, at the side, in superscript.
- Tsunami - "F.A.G. Filter" (S. Ross)
- Tammy Boness & The Swingin' Mammaries - "The Diner" (J. Wemyss, C. Conner)
- Voice Box - "Computer Lust" (S. Ross)
- Rev. Rooney & The Rocksta Choir - "God Bless All The Universe" (C. Conner)
- After "F.A.G. Filter", Spaz says "let's have another hit" and he plays, although briefly, 2 songs from GTA: Slumpussy's "This Life", from N-CT FM, and Stikki Fingers' "4 Letter Love", from It's Unleashed FM.
- During the news report, it plays Da Shootaz's "Grand Theft Auto", from N-CT FM in GTA.
- Rev. Rooney & The Rocksta Choir's "God Bless All The Universe" contained profanities during the Beta stages of development, which were cut for the final version.
- The radio of GTA Advance includes an instrumental version of Voice Box's "Computer Lust".