The neighborhood comprises of medium rise, expensive apartments, which are mainly inhabited by business people. One of the girlfriends that Niko can meet, Alex Chilton, lives in a rich apartment in Lancaster, and the Myroom user Francis "Little Frankie" Ferguson aka "Pimpdog1620" states he lives in Lancaster meaning he comes from a very rich family. Huang Lee also owns an apartment in Lancaster. A Terroil filling station is located on Albany Avenue, Lancaster. In 2009, a portion of the area neighboring East Holland is under control of the Spanish Lords.
The name of the neighborhood is a reference to the Wars of the Roses between the Houses of Lancaster and York, given that is based on the New York City neighborhood of Yorkville.