The hospital is situated in southeast Lancet, Algonquin, Liberty City, consisting of a large building occupying an entire city block bordered by Jade Street, Albany Avenue, Kunzite Street (part of the Algonquin Bridge on ramp) and Bismarck Avenue. Like most other hospitals, the building lacks an interior (being insignificant to the development of the game's storyline), but spawns Ambulances on the Bismarck Avenue side, and also includes a health pack on the eastern entrance of the south side, as well as ECola vending machines at its entrances. The hospital also features a heliport (accessible only by air), as well as a tall smokestack. It also houses a rehab and STD clinic as seen on I'm Rich.
The building is officially named "Easton Medical Center" on Peep That Shit's tourism website under "hospitals", however the building itself is actually located in Lancet, as supported by signage on the arched western entrance on the south side of the building, with a hyphen between "Lancet" and "Hospital" included within the name. In addition, a subtitle that reads "St. Openshaw" accompanies the Lancet-Hospital Center signage.
The building closely resembles the NYU Langone Medical Center, in real life located in the Kips Bay area of Manhattan, upon which Lancet itself is based.