Various radio commercials are featured on the radio stations of Grand Theft Auto: San Andreas. The game introduced randomizing mechanics for radios so any of these commercials can play randomly on any station, with the exception of the Special Needs Cop commercial, which can only be heard on WCTR.
Commercials that reference events in game:
- American Bank of Los Santos — A commercial about bank loans, has the same music as the Little Lacy Surprise ad in GTA Vice City Stories.
- Ammu-Nation — (Intro voiced by Frank Chavez) Advertising guns sold within the stores, telling everyone why they should all buy and own a gun whilst using strong anti-Liberal messages. The Ammu-Nation commercial from Grand Theft Auto: Vice City can be heard inside all of the stores throughout the state.
- Blotto's (Three commercials) — A store catering for daily habits.
- Bouche Cologne — A cologne advertised for the man who wants to feel like a real man. This is the first of two different colognes that are advertised on the radio within the game.
- Castradon — A baldness remedy that eliminates Testosterone and attacks the glands that produce it.
- Celebrate with Cake — (Two commercials) An advert encouraging emotional eating and obesity afterwards.
- Cluckin' Bell (Two commercials) — A commercial for the fried chicken chain in-game, which is a parody of KFC. The commercials make references to KFC's many controversies, including accusations of cruelty to chickens.
- Inversion Therapy (Danny Burstein) — A form of therapy to overcome rather extreme fears by facing them, parodying the discredited aversion therapy. Creator Darius Fontaine calls in on the final Entertaining America, Lazlow having tried the therapy unsuccessfully.
- My Five Uncles — A TV series of which is both a parody of My Two Dads and Full House. The show is about an "emotionally abused orphan" teenage girl who is adopted by five gay men. The show is broadcast on the fictional channel LSBC.
- Proposition 421 — A proposition against smoking, which would allow a citizen to legally shoot and kill a smoker in self-defense. The name is a reference to 420, a slang term for marijuana.
- The Cavern of Sorrow — A Medieval role-playing game based on Dungeons & Dragons Dungeons & Dragons.
- The Epsilon Program (Fred Melamed, three commercials) — A cult that offers "eternal salvation for those who attend" and as being the true American cult. Numerous people in the game appear to be members including original Entertaining America host Billy Dexter and Area 53 host Marvin Trill. Epsilon Program founder Cris Formage is interviewed by Lazlow on the third and final segment of Entertaining America. Dwayne Thorn, from VCPR in Grand Theft Auto: Vice City Stories also utters the Program's mantra "Kifflom" at one point, as does VCFL DJ Tina Jane, who insults the cult.
- Ultimate Disk in the Dark — A San Fierro-based game where players throw a flying disc in the dark, the object is to catch a disc and run to the goal to score.
- Zebra Bar (Ed McMann; two commercials) — An exotic chocolate bar that mixes white chocolate with dark chocolate.
Other Commercials:
- Abbigo Brokerage and Pawn — Trade in absolutely anything in exchange for cash.
- Carcer City Vacations — Commercial advertising Carcer City as a holiday destination for those who are "tired of all the sunshine and good weather". Carcer City is the setting of the Rockstar North title Manhunt.
- Commando Pest Eradication — A radical team of Vietnam veterans acting as insect exterminators. "It's the War on Nature; and this time, we're winning."
- Commemorative Miniatures — A historical miniature wargaming commercial, selling miniatures soldiers and tanks. General Custer, Napoleon, the Charge of the Light Brigade and the Trail of Tears are mentioned.
- Creative Plastic Surgery — A plastic surgery clinic promoting unusual changes such as tails or a third breast.
- Crimson Executive Spouse Indemnity Services (1-866-505-CRIM) — Easily obtainable legal service offering life insurance policies for husbands in case their wives suffer terrible "accidents" (similar to the D'Leo and Thurax commercial from GTA Vice City.) The customers in both testimonials are strongly implied to have murdered their spouses to cash in on their new insurance coverage. Possibly a reference to Monty Python's Crimson Permanent Assurance.
- Don't let Your Children Ride Bicycles — Do the motherly thing and buy your child an over-powered sports car instead of a bike. A public service announcement sponsored by The Governor’s Office of San Andreas, in association with Maibatsu Cars of America.
- Dreamakers — Talent agency where nobodies are trained to become "stars". Based in Vinewood.
- Eris Pump Up Shoes — A sports shoe commercial which parodies the mid-90s obsession with Reebok Pump shoes. The Eris brand previously featured in a commercial in Grand Theft Auto III. The advertising was voiced by Sean R. Lynch.
- Executive Intruder Extermination Services — Personal security service offering protection for wealthy paranoids.
- EXsorbeo — A portable game console. The commercial equates playing games on the system with masturbation, with such lines as, "Look mom, I'm playing with myself!" and "don't play too long or you'll go blind". The console has its own website.
- Fokari Film — Photographic film developing company. "Memories are forever...sort of."
- Glory Hole Theme Park — (Mike Blakeney, two commercials) A theme park that caters to unconventional sexual behavior but presents itself as a family amusement park. "Gloryhole! Where strangers become friends! Gloryhole! You don't need to know names!"
- Grin — A medication that cures the depression and anxiety that one gets from living life in the suburbs.
- Hampshire Nannies — Company offering strict classical British style nannies. The narrator is "Freddy", the nanny and spanking obsessed caller in previous Grand Theft Auto games.
- Herr Gruber's Spa — An international spa business owned by Herr Gruber, who has opened spas all around the world including such countries as Germany, Switzerland and Brazil.
- Ice Diamonds/De Koch Diamonds — The perfect gift for your partner: "chill that bitch out, with ice."
- Intergalactic Wrestling Title — A spoof of American professional wrestling that is also broadcast on Weasel.
- Janus — Service to help people alienate their family to protect their new west coast identities.
- Join the Military — Recruiting commercial for the military with the usual GTA touch.
- Kilimanjaro (Two commercials) — A clothes shop "for the Obesity bigger men."
- Law (Jeff Berlin, three commercials) — Legal drama series broadcast on Thursdays on cable channel Weasel. A parody to legal shows such as L.A. Law.
- Logger Beer (Ed MacMann) — "The beer that brought the forest down!"
- Logger Light (Ed MacMann) — A low calorie diet version which "facilitate[s] alcoholism without the attendant weight gain."
- Lustrious — (Two commercials) A hair styling product.
- Midlife Crisis Center — Services provided for middle aged men who want to regain their youth. (Specializing in real estate, divorce attorneys, mistress placement, plastic surgery, hair colouring and replacement, and male fur coats.) "Come with your wife, leave with a sports car."
- Mike Andrews (Two commercials) — A self-help guru promoting a "less is more" approach to wealth for the poor.
- Proposition 602 — A proposition to end mass-transit, converting bus-lanes and train tracks into more roads for the benefit of car owners.
- Proposition 832 — B.I.G.O.T. (Ban Immigration Green Cards Outright Today) An organization aiming to ban immigration and instead create a new status for illegal aliens, whereby "while they're here, they have no rights." The ad also claims, "If we give them green cards, soon they’ll be just like us - overweight, unhappy, and too lazy to do menial tasks".
- Rapidite — The do-it-yourself sexual realignment kit: the quickest and latest way to change your sex. "It's just snip, chop, stuff & swallow. Four quick actions with amazing effects."
- Redwood Cigarettes — A brand of cigarette that "helps cure stress". With sponsorship of Los Santos City Marathon.
- Renegade Cologne (Jeff Berlin) — "For the man who wants to reek of masculinity."
- San Andreas Telephone — (Four commercials) The commercials parody numerous "stay in touch with loved ones" phone company advertising campaigns.
- Shine by Helmut Schein — Designer perfume. Voiced by Jodie Shawback. Shawback also voices the Radio-X DJ 'Sage'. She is the only in-game DJ to also be in an in-game radio commercial.
- Sooth — A hallucinogenic cold and cough syrup made from codeine, morphine, and alcohol. Also available for children as Sooth Junior. May be partially inspired by purple drank, a recreational drug popular in Southern hip-hop culture.
- Special Needs Cop (Randy Pearlstein, Jeff Berlin, Ron Reeve, Mike, Chris and James Ferrante and Chris Silvestro) — A movie starring action star Jack Howitzer (from the "Exploder" movie in Vice City) as a cop going undercover in a school for special-needs kids. A spoof on Kindergarten Cop.
- Sprunk — An explosive re-energizing soft drink carbonated with ether. The Sprunk logo and colour scheme bear a strong resemblance to those of Sprite. A Sprunk factory can be found situated in one of Red County's country villages. There is also a Sprunk advertising board in Los Santos, which CJ crashes a car into during the mission "Reuniting the Families", the catch phrase on the board originally said A Taste of Things to Come, but after the crash, only the words A Taste of Come is left, referring to the word cum: (ejaculation - semen). A commercial is heard on the radio, saying that Sprunk now has a grenade shaped can. A radio ad for a Sprunk sweepstakes offers customers a chance to win a real box of grenades.
- Starfish Resort and Casino — Casino targeting children as well as adults.
- The Crazy Cock — A strip club where the women know how to entertain "gentlemen".
- Tropicarcinoma — Anti-tan-cream made from coconut oil, zinc, aluminum, boron, magnesium, and other volatile metals.