The Central Los Santos Medical Center serves the southern neighborhoods of Los Santos. It is bordered by Capital Boulevard, Crusade Road, Davis Avenue and Innocence Boulevard, in the eastern side of Strawberry. It is likely based on the LAC+USC Medical Center of Los Angeles. Players will spawn here if it is the closest hospital upon being wasted.
According to signage, the hospital has departments of Urology, Radiology, Ultrasound, Endoscopy and Medical Physics, as well as an emergency room and a chapel. The hospital is connected to its own parking center via an inaccessible walkway just across Davis Avenue. This carpark is labeled as 'Medical Center Parking' by signs so presumably is for hospital patients use only, rather than general public.
Due to its location in a heavily gang populated area, the hospital is presumably quite busy and is always receiving patients (ambulances will often be seen leaving the hospital on calls). The medical center has also gained negative criticism for its bad doctors and healthcare in TV commercials of Mount Zonah Medical Center.
According to a Mount Zonah Medical Center TV commercial, Los Santos Medical Center's treatment caused the death of a son's father. The commercial voice, who also voices the GTA IV male GPS voice, advises patients to visit the Mount Zonah Medical Center instead. Doctors appear beating the patient, suggesting the LSMC use otherwise "controversial" treatment. During the commercial, dying patients are seen within the hospital corridors (despite the interior being the GTA IV hospital interior.
- Ambulances spawn frequently on the hospital's parking lot. These can come in several liveries including the generic Mission Row SA livery and the more specific Los Santos Medical Center livery.
- One or two Air Ambulances can also spawn on the hospital's roof, which can be accessed via the ladders (and stairs), though it may take a few visits to spawn.
- In Grand Theft Auto Online, the player can find helicopters like the Maverick, Buzzard and Cargobob on the helipad after achieving certain ranks.
- One of the 50 spaceship parts can be found on the roof.
- The hospital's logo is the Rod of Asclepius, a serpent-entwined rod that is the symbol of medicine and health care.
- Gang members such as those from the Varrios Los Aztecas and Los Santos Vagos will sometimes spawn on the sidewalks behind the hospital.
- County General Hospital - Grand Theft Auto: San Andreas equivalent to Central Los Santos Medical Center.