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Big Wayne is a dealer who lives in Glen Park, Los Santos. Radio Los Santos's DJ Julio G gives him a shout out, and Big Wayne himself even calls in at one point saying: "This is Big Wayne, I've got a special price on Z's, hit me up".

Big Wayne is voiced by "Big" Wayne Oliver, who also voiced the Vice City Bikers in Grand Theft Auto: Vice City Stories, as well as a radio station caller in Grand Theft Auto: Vice City.

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