Presented by Lazlow Jones, America's Next Top Hooker is a competitive reality television show where the female contestants compete against each other to prove that they are the best hooker (often involving performing sexual acts with multiple partners or for an extended period of time). It is clearly a parody of America's Next Top Model.
The show appears on the CNT lineup, but cannot be viewed on any of the protagonists' televisions. During one of its radio commercials, the announcer states that Crystal won the previous season of ANTH. The commercials sponsoring the show can be heard on most of the radio stations in Liberty City, and the show is also advertised on the sides of Liberty City buses.
- The show's theme song can be downloaded from VIP Luxury Ringtones as a ringtone for the player's cell phone. A wallpaper with the ANTH logo is also available.
- The font on the show's logo appears to be based on that of the British television series Top Gear.
- Before the song "Wet Em Up" by Tru Life plays, the DJ will announce on The Beat 102.7 that "America's Next Top Hooker will be in the building!"
- In the mission Friend Request during Grand Theft Auto V, the theme for the show will sometimes play as the theme for the pop-up viruses the player must remove during the mission. It is very hard to hear it, however, as they are mixed in alongside another ringtone and the dialogue that plays between Michael De Santa and Rickie Luckens.