Portland Story Missions
- Mike Lips Last Lunch
- Farewell 'Chunky' Lee Chong
- Van Heist
- Cipriani's Chauffeur
- Dead Skunk in the Trunk
- The Getaway
Staunton Island Story Missions
- Waka-Gashira Wipeout
- A Drop In The Ocean
- Grand Theft Aero
- Escort Service
- Love's Disappearance
Shoreside Vale Story Missions
Remote Controlled Vehicle Missions
- Paramedic (Level 12, save 78 patients)
- Firefighter (Extinguish 60 fires, 20 on each island)
- Vigilante (Kill 60 criminals, 20 on each island)
- Taxi Driver (Complete a number of 100 fares)
- Emergency Vehicle Import/Export Crane
- Industrial Import/Export Garage List (Portland)
- Suburban Import/Export Garage List (Shoreside Vale)
- After completing Last Requests, any remaining missions for Luigi Goterelli, Joey Leone and Toni Cipriani will be permanently disabled, preventing the player from achieving 100% completion.
- After completing Waka-Gashira Wipeout, any remaining missions for Kenji Kasen will be permanently disabled, also preventing the player from achieving 100% completion.
- Unlike succeeding Grand Theft Auto games, there are no rewards at 100% completion.
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