De norte a sul, começa no West Eclipse Boulevard, paralelo ao Mad Wayne Thunder Drive, terminando no cruzamento com a Dorset Drive, onde se torna a Palomino Avenue.
A rua também tem conexões para Edwood Way, Spanish Avenue, Caesars Place, Boulevard Del Perro, South Boulevard Del Perro, Eastbourne Way e Carcer Way.
Portola Drive é uma popular área de compras e atração turística em Los Santos e muito parecido com o resto do bairro, é conhecida por sua atmosfera high-end e caro, onde muitas celebridades pairam sobre em seu tempo de lazer. O trecho sul de Portola Drive também inclui um beco apenas para pedestres conhecido como Little Portola, perto do cruzamento com Eastbourne Way, baseado no mundialmente famoso Rodeo Drive. Por outro lado, o trecho norte é basicamente residencial.
Elgin Avenue | Hawick Avenue | Little Bighorn Avenue | San Andreas Avenue | Strawberry Avenue
Ruas
Alta Street | Atlee Street | Low Power Street | Peaceful Street | Power Street | Sinner Street | Swiss Street
Vias
Integrity Way
Outras
Adam's Apple Boulevard | Fantastic Place | Las Lagunas Boulevard | San Andreas Avenue Bridge* | Sinners Passage | Vespucci Boulevard | Vespucci Boulevard Bridge*
Clinton Avenue | Elgin Avenue | Hawick Avenue | Nikola Avenue | North Archer Avenue | Occupation Avenue | San Andreas Avenue | Spanish Avenue
Ruas
Alta Street | Bridge Street | Meteor Street | Power Street | Tangerine Street | York Street
Travessas
Gentry Lane
Vias
Eastbourne Way | Glory Way
Estradas
Baytree Canyon Road
Pistas
East Mirror Drive | Strangeways Drive | Vinewood Park Drive | West Mirror Drive
Outras
Alta Place | Eclipse Boulevard | Fenwell Place | Laguna Place | Las Lagunas Boulevard | Mirror Park Boulevard | Mirror Place | Nikola Place | Utopia Gardens | Vinewood Boulevard
Amarillo Vista | Dry Dock Street | Dutch London Street | Popular Street | South Shambles Street | Supply Street
Travessas
Fudge Lane
Vias
Amarillo Way | Hanger Way | Tower Way
Estradas
Sustancia Road
Outras
Capital Boulevard | Dutch London Street Bridge* | El Burro Boulevard | El Rancho Boulevard | Innocence Boulevard | Labor Place | San Andreas Avenue Bridge* | Vespucci Boulevard | Vespucci Boulevard Bridge*
Bay City Avenue | Magellan Avenue | Palomino Avenue | San Andreas Avenue
Ruas
Aguja Street | Conquistador Street | Cortes Street | Goma Street | Imagination Court | Invention Court | Melanoma Street | Prosperity Street | Rub Street | Tug Street | Vitus Street
Pistas
South Rockford Drive
Outras
Vespucci Boulevard
Avenidas
Calais Avenue | Cougar Avenue | Hangman Avenue | Hillcrest Avenue | Marathon Avenue | North Conker Avenue | North Sheldon Avenue | Red Desert Avenue | Spanish Avenue
Ruas
Decker Street | Dutch London Street | Ginger Street | Liberty Street | Perth Street | Playa Vista | Richman Street | Shank Street | South Arsenal Street | South Boulevard Del Perro | South Mo Milton Drive | South Rockford Drive | Tackle Street
Travessas
Dunstable Lane
Vias
Abe Milton Parkway | Americano Way | Autopia Parkway | Carcer Way | Cox Way | Edwood Way | Equality Way | Exceptionalists Way | Greenwich Parkway | Greenwich Way | Hanger Way | Hardy Way | Heritage Way | Movie Star Way | New Empire Way | Sandcastle Way | Steele Way
Bay City Incline | Boulevard Del Perro | Caesars Place | Dorset Place | Greenwich Place | Industry Passage | Land Act Dam | Lake Vinewood Estate | Lindsay Circus | Morningwood Boulevard | San Vitus Boulevard | West Eclipse Boulevard
Autoestradas
Los Santos Freeway | Del Perro Freeway | Olympic Freeway | La Puerta Freeway
