Python

The Colt Python is the most accurate pistol and only revolver available in the GTA III Era series of games. It also shares the record for being the most powerful pistol with the Desert Eagle, although the Desert Eagle edges it out, being a .50AE instead of a .357. The Colt Python was first revealed in Grand Theft Auto: Vice City, and is available to the player on Vice City's main island, Ammu-Nation for $2000, spawnable in Vercetti Estate, and discoverable in several locations. The high cost of the revolver (compared to the M1911's modest $200 price tag) comes with the reward of it being almost guaranteed to kill any target with a single shot. However, the gun cannot be fired while running, and must be fired from a Weaver position (grasping the butt of the gun with the right hand, then cradling the right hand and gun with the cupped left hand, all while planting feet at a wide stance) due to the heavy recoil of the .357 Magnum cartridge. It also has a moderate cylinder capacity of 6 shots, making it excellent against small groups. The Python is also available in Grand Theft Auto: Liberty City Stories, and the version in Grand Theft Auto: Vice City Stories features a laser scope and an 8" barrel (as opposed to the original 6"), although the scope can not be used.

GTA Vice City

 * In the record room of the Vercetti Estate after completing Keep Your Friends Close....
 * Available to buy from the Downtown Ammu-Nation for $2,000.
 * In an alley near the 'Welcome to Hell' billboard in Little Haiti.
 * Available at the Ocean View Hotel after finding 30 hidden packages.

GTA Liberty City Stories

 * At the Francis International Airport on a roof behind a billboard, the roof can be reached by a ramp.
 * Spawns at each safehouse after finding 50 hidden packages.

GTA Vice City Stories

 * To the left of the Jetski that activates the Watersports courses, on the InterGlobal Films studio.
 * Hidden at the hotel not far Lance's House.
 * Available at each safehouse after bursting 80 red balloons.

Trivia

 * Rockstar renamed the Colt Python to .357 in later versions of GTA Vice City, possibly to avoid copyright and trademark infringements.
 * The Colt Python is called ".357" in GTA Liberty City Stories, and the GTA Vice City Stories refers to the gun as Equalizer.
 * It was originally going to be featured in Grand Theft Auto IV, as seen in a beta screenshot.